Introduction – Important secret messages can be transferred from one part of the body to another by using cells which secrete Nanoscale packets through exosomes. A new method is introduced to understand these messages by the top scientists. This method can be used to detect other problems or diseases like cancer or fetal abnormalities. It uses the various combinations of sound waves and microfluidics which helps in the isolation of exosomes from the blood of your body.
Researches – The researchers made their efforts by the integration of this technology into a portable device which helps in the analysis of blood samples for finding the recent problems. This process does not involve the complex and time-consuming ultra-centrifugation method which is widely used by most of the researchers. Different abnormalities are displayed through the specific molecules contained by the exosomes. A different consequence is generated by doing biological analysis through the isolation of blood from the molecules generated.
Process – A tiny channel is used for the flow of blood which is exposed by the isolation of blood cells and sound waves. There is an alternative for cell-sorting technologies which requires cell tagging with chemicals and their exposure to more stronger mechanical forces which can damage them completely. Later, it is found that this technology can also be used to separate tumor cells from the blood which is very rarely found. By this, they started capturing exosomes. These vesicles carry important cellular molecules like protein and RNA, etc. which contains proteins.
Problem detector – The contents of the exosomes helps in the identification of various disorders like cancer, neurodegenerative disease, and kidney disease. Although, methods which are already existed requires high-speed centrifugation. It requires performance of 24 hours by using large non-portable machine. The high centrifugal forces help in the damage of these vesicles. Researchers use acoustic cell-sorting device which expose microfluidic channel. There is a pressure which guides the cell by encountering the transducers into one another. Size and other properties of these cells are the main reason for the distance in cell movements. These properties include compressibility. It helps in the separation of different sizes of cells which reach in the end of the channel.
Device – A device is developed which shows two units, which suggests, the removal of cells and platelets from the sample of blood uses sound waves. When the cells and the platelets are removed, the blood sample enters the second unit of micro fluids, which further uses other sound waves for receiving great frequency for the separation of exosomes from large extracellular vesicles. It uses unique combination of human fluidic samples and acoustics with the use of micro-fabrication technologies.
